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Literature summary for 3.4.22.27 extracted from

  • Klinngam, W.; Fu, R.; Janga, S.R.; Edman, M.C.; Hamm-Alvarez, S.F.
    Cathepsin S alters the expression of pro-inflammatory cytokines and MMP-9, partially through protease-activated receptor-2, in human corneal epithelial cells (2018), Int. J. Mol. Sci., 19, E3530 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.27

Application

Application Comment Organism
medicine cathepsin S activation of PAR-2 may represent a potential therapeutic target for amelioration of ocular surface inflammation in Sjögren's syndrome patients Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene CTSS, real-time PCR enzyme expression analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens cathepsin S-dependent activation of PAR-2 activation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P25774
-
-

Source Tissue

Source Tissue Comment Organism Textmining
corneal epithelial cell
-
 Homo sapiens
-
eye
-
 Homo sapiens
-
HCE-T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cathepsin S-dependent activation of PAR-2 activation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CTSS
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens CTSS gene expression is increased after cells have been treated with recombinant CTSS for 24 h. CTSS protein expression in cell lysates measured using the human CTSS ELISA kit also reveal that the protein increases after 8 h CTSS treatment up

General Information

General Information Comment Organism
malfunction cathepsin S (CTSS) activity is increased in tears of Sjögren's syndrome patients. This elevated CTSS may contribute to ocular surface inflammation. Cells with reduced PAR-2 expression show reduced ability of chronic CTSS to induce gene expression of pro-inflammatory cytokines and proteases. Acute exposure to heat-inactivated CTSS does not induce pro-inflammatory cytokines Homo sapiens
physiological function cathepsin S alters the expression of pro-inflammatory cytokines and MMP-9, partially through protease-activated receptor-2, in human corneal epithelial cells. Acute CTSS exposure significantly increased HCE-T cell gene and protein expression of interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) from 2 to 4 h, while matrix metalloproteinase 9 (MMP-9), CTSS, and protease-activated receptor-2 (PAR-2) are increased by chronic CTSS exposure Homo sapiens